What drug is morphine

Added: Robin Massengill - Date: 21.09.2021 18:47 - Views: 32005 - Clicks: 1102

Morphine is an opioid agonist used for the relief of moderate to severe acute and chronic pain. Morphine, the main alkaloid of opium, was first obtained from poppy seeds in Morphine was granted FDA approval in Morphine is used for the management of chronic, moderate to severe pain. Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Morphine binding to opioid receptors blocks transmission of nociceptive als, als pain-modulating neurons in the spinal cord, and inhibits primary afferent nociceptors to the dorsal horn sensory projection cells. Morphine has a time to onset of minutes. Intravenous morphine's analgesic effect is sex dependent. Morphineglucuronide is 22 times less potent than morphine in eliciting pupil constriction. Morphine's activation of the reward pathway is mediated by agonism of the delta-opioid receptor in the nucleus accumbens, 2 while modification of the respiratory system and addiction disorder are mediated by agonism of the mu-opioid receptor.

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Morphine is absorbed in the alkaline environments of the upper intestine and rectal mucosa. Morphine reaches steady-state concentrations after hours. The volume of distribution of morphine is 5. Morphine has a half life of hours. The LD 50 is 0. Patients experiencing an overdose present with respiratory depression, somnolence, skeletal muscle flaccidity, cold and clammy skin, miosis, and mydriasis. Symptoms of overdose can progress to pulmonary edema, bradycardia, hypotension, cardiac arrest, and death.

Interactions Drug Interactions Food Interactions. Clinical Trials. Spectra Mass Spec Spectra. Targets 4. Enzymes 8. Carriers 1. Transporters 1.

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Identification Summary Morphine is an opioid agonist used for the relief of moderate to severe acute and chronic pain. With our commercial data, access important information on dangerous risks, contraindications, and adverse effects. Learn more. This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately.

The absence of an interaction does not necessarily mean no interactions exist. Drug Interaction Integrate drug-drug interactions in your software. Improve patient outcomes. From application s to product codesconnect different identifiers through our commercial datasets. Download KB. Download King pharmaceuticals inc Actavis elizabeth llc Ekr therapeutics inc App pharmaceuticals llc Baxter healthcare corp anesthesia and critical care Hospira inc Mallinckrodt chemical inc Meridian medical technologies inc Watson laboratories inc Roxane laboratories inc Clonmel healthcare ltd Endo pharmaceuticals inc What drug is morphine pharmaceutical co Mallinckrodt inc Purdue pharma lp Xanodyne pharmaceutics inc Actavis.

Barr Pharmaceuticals Baxter International Inc. Cody Laboratories Inc. Graham Laboratories Inc. Elan Pharmaceuticals Inc. Endo Pharmaceuticals Inc. Ethex Corp. Hi Tech Pharmacal Co. Hospira Inc. Ide Interstate King Pharmaceuticals Inc. KV Pharmaceutical Co. Lehigh Valley Technologies Inc. Ligand Pharmaceuticals Inc. Mallinckrodt Inc. Marathon Pharmaceuticals Mckesson Corp. Meridian Medical Technologies Inc. P F Laboratories Inc. Pacira Pharmaceuticals Inc. Xanodyne Pharmaceuticals Inc. DrugBank does not sell nor buy drugs.

Pricing information is supplied for informational purposes only. Targets Accelerate your drug discovery research. General Function Voltage-gated calcium channel activity Specific Function Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone Brain Res. Epub Mar Biochem Biophys Res Commun. Osteoarthritis Cartilage. Mol Pharmacol. Epub May 8. Nucleic Acids Res. General Function Opioid receptor activity Specific Function G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins.

Also functions as receptor for various synt Nat Rev Drug Discov. J Pharmacol Exp Ther. Epub Jun 6. General Function Opioid receptor activity Specific Function G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers aling via guanine n J Neurochem.

Epub May 2. Eur J Pharmacol.

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Epub Apr 6. Prog Neurobiol. Epub Feb General Function Steroid hydroxylase activity Specific Function Cytochromes P are a group of heme-thiolate monooxygenases. It oxidizes a variety of structurally un General Function Vitamin d3 hydroxylase activity Specific Function Cytochromes P are a group of heme-thiolate monooxygenases. It performs a variety of oxidation react Biol Pharm Bull. General Function Glucuronosyltransferase activity Specific Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Its unique specificity for 3,4-catechol estrogens and estriol su Drug Metab Dispos. Epub Dec J Toxicol Sci. Epub Jan General Function Steroid binding Specific Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

This isoform glucuronidates bilirubin IX-alpha to form both the Isoform 2 lacks transferase activity but acts as a negative reg General Function Glucuronosyltransferase activity Specific Function UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xeno This isozyme is active on polyhydroxylated estrogens such as General Function Retinoic acid binding Specific Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Its main What drug is morphine is the regulation of the colloid Anesth Analg. Epub Oct General Function Xenobiotic-transporting atpase activity Specific Function Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. J Med Chem. Pharm Res. Show full image. A Mu-type opioid receptor. A Kappa-type opioid receptor.

A Delta-type opioid receptor. U Lymphocyte antigen Morphine Action Pathway. Codeine Action Pathway. Heroin Metabolism Pathway. Heroin Action Pathway. Codeine Metabolism Pathway. Morphine Metabolism Pathway. T Allele. Effect Directly Studied.

What drug is morphine

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morphine (injection)