Added: Mariadelcarmen Tallant - Date: 11.10.2021 11:55 - Views: 30034 - Clicks: 3514
Ketamine was developed in the early s as an anesthetic and has been used for medical and veterinary procedures since then. Its unique profile of effects has led to its use at subanesthetic doses for a variety of other purposes: it is an effective analgesic and can prevent certain types of pathological pain; it produces schizophrenia-like effects and so is used in both clinical studies and preclinical animal models to better understand this disorder; it has rapid-acting and long-lasting antidepressant effects; and it is popular as a drug of abuse both among young people at dance parties and raves and among spiritual seekers.
In this article we summarize recent research that provides insight into the myriad uses of ketamine. Clinical research is discussed, but the focus is on preclinical animal research, including recent findings from our own laboratory. Of particular note, although ketamine is normally considered a locomotor stimulant at subanesthetic doses, we have found locomotor depressant effects at very low subanesthetic doses.
Thus, rather than a monotonic dose-dependent increase in activity, ketamine produces a more complex dose response. Additional work Drug abuse ketamine the mechanism of action of ketamine, ketamine-induced neuroadaptations, and ketamine reward.
The findings described will inform future research on ketamine and lead to a better understanding of both its clinical uses and its abuse. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.
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of items displayed: 5 10 15 20 50 Create RSS Cancel. RSS Link Copy. Full text links Cite Display options Display options. Abstract Drug abuse ketamine was developed in the early s as an anesthetic and has been used for medical and veterinary procedures since then. Similar articles Increased response to ketamine following treatment at long intervals: implications for intermittent use. Trujillo KA, et al. Biol Psychiatry. Epub Jun PMID: Ketamine abuse potential and use disorder. Liu Y, et al.
Brain Res Bull. Epub May PMID: Review. Ketamine sensitization: Influence of dose, environment, social isolation and treatment interval. Behav Brain Res. Epub Oct 5. Intensive ketamine use for multiple years: A case report.
Liu JX, et al. Am J Addict. Ketamine years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms. Kohtala S. Pharmacol Rep. Epub Feb See all similar articles. Silva-Cardoso GK, et al. Neurochem Res. Epub Mar Investigation of urinary components in rat model of ketamine-induced bladder fibrosis based on metabolomics.
Li H, et al.
Transl Androl Urol. Ketamine: Leading us into the future for development of antidepressants. Carreno FR, et al. Epub Feb 2. Urinary metabonomics of rats with ketamine-induced cystitis using GC-MS spectroscopy. Wu ZG, et al. Int J Clin Exp Pathol. Abiero A, et al. Psychopharmacology Berl. Epub Dec See all "Cited by" articles. Publication types Research Support, N. MeSH terms Analgesics Actions. Animals Actions.
Behavior, Addictive Actions. Humans Actions. Substance-Related Disorders Actions. Substances Analgesics Actions. Antidepressive Agents Actions. Ketamine Actions. Show all 6 grants. Copy Download.Drug abuse ketamine
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